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TSH RECEPTOR ANTIBODY SYNTHESIS BY THYROID LYMPHOCYTES
Author(s) -
MCLACHLAN S. M.,
PEGG C. A. S.,
ATHERTON M. C.,
MIDDLETON S. L.,
CLARK F.,
SMITH B. REES
Publication year - 1986
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1986.tb00766.x
Subject(s) - endocrinology , medicine , receptor , antibody , thyroid , lymphocyte , immune system , immunology , biology
Several indirect observations have indicated that lymphocyte in the thyroid may be an important site of TSH receptor antibody synthesis in Graves’disease and we now describe an investigation of this possibility using improved lymphocyte isolation and TSH receptor antibody assay procedures. Our studies demonstrate that thyroid Iymphocytes spontaneously produce TSH receptor antibody in culture. Furthermore, experiments with mitogen tend to suggest that these cells, in contrast to lymphocytes from lymph nodes draining the thyroid, are part of an active immune response to the TSH receptor.