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PARATHYROID HORMONE‐LIKE BIOACTIVITY IN TUMOURS FROM PATIENTS WITH ONCOGENIC OSTEOMALACIA
Author(s) -
SESHADRI MANDALAM S.,
CORNISH C. J.,
MASON R. S.,
POSEN S.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb01130.x
Subject(s) - osteomalacia , endocrinology , medicine , parathyroid hormone , adenylate kinase , cyclase , parathyroid hormone receptor , pseudohypoparathyroidism , hormone , receptor , antagonist , hormone receptor , calcium , vitamin d and neurology , cancer , breast cancer
SUMMARY Extracts from the tumours of three patients with oncogenic osteomalacia stimulated renal adenylate cyclase in a parathyroid hormone (PTH) responsive system. The stimulation was suppressed by a specific PTH antagonist. These observations suggest that osteomalacia‐producing tumours exert some of their effects through PTH‐like material acting on PTH receptors.