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IDENTIFICATION AND CHARACTERIZATION OF THE HUMAN HEPATIC ANDROGEN RECEPTOR
Author(s) -
BANNISTER P.,
SHERIDAN P.,
LOSOWSKY M. S.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb01108.x
Subject(s) - cytosol , size exclusion chromatography , androgen receptor , human liver , endocrinology , androgen , medicine , testosterone (patch) , receptor , biochemistry , chemistry , molecular mass , biology , in vitro , hormone , enzyme , prostate cancer , cancer
SUMMARY Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) present in cytosol alone and a low molecular weight component (mol wt. 75 000) present in cytosol and nucleosol. Human liver contains the classical androgen receptor.