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RESTORATION OF DEXAMETHASONE SUPPRESSION BY INCOMPLETE ADENOMECTOMY IN CUSHING'S DISEASE
Author(s) -
JEFFCOATE W. J.,
DAUNCEY S.,
SELBY C.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00215.x
Subject(s) - dexamethasone , medicine , endocrinology
SUMMARY Two cases of pituitary‐dependent Cushing's disease are described. Selective transphenoidal adenomectomy was attempted in each, but proved incomplete. Although both patients had persistent Cushing's disease after the operation, both were shown to have been rendered fully dexamethasone suppressible. The pathophysiological basis of partial suppressibility is discussed, as are the criteria for the diagnosis of cure in Cushing's disease treated by selective adenomectomy.