Premium
SOMATOSTATIN AND WATER EXCRETION IN MAN: AN INTRARENAL ACTION
Author(s) -
WALKER B. J.,
EVANS P. A.,
FORSLING M. L.,
NELSTROP G. A.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00212.x
Subject(s) - endocrinology , medicine , somatostatin , excretion , action (physics) , physics , quantum mechanics
SUMMARY Intravenous infusion of somatostatin in six water loaded normal human subjects produced a prompt reduction in urine flow accompanied by a rise in urine osmolality and a decrease in free water clearance. Plasma AVP levels did not change. Somatostatin would seem to exert an antidiuretic effect directly on the kidney.