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THE EFFECTS OF CHOLINERGIC BLOCKADE ON THE GROWTH HORMONE AND PROLACTIN RESPONSE TO INSULIN HYPOGLYCAEMIA
Author(s) -
EVANS P. J.,
DIEGUEZ C.,
FOORD S.,
PETERS J. R.,
HALL R.,
SCANLON M. F.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00163.x
Subject(s) - endocrinology , medicine , insulin , atropine , prolactin , cholinergic , blockade , hormone , growth hormone , pancreatic hormone , placebo , insulin resistance , receptor , alternative medicine , pathology
SUMMARY The effect of cholinergic blockade on growth hormone (GH) and prolactin (PRL) secretion during insulin‐induced hypoglycaemia was assessed in six normal male volunteers (mean age 23, age range 21–25). Each subject underwent two insulin tolerance tests with and without atropine. GH responses were significantly lower 45 min after insulin administration with atropine (17.5 · 2.5 mU/l (mean · SEM) than with placebo (37.6 · 3.6 mU/l, P < 0.0006). In contrast PRL responses were higher ( P < 0.01) at 45 and 90 min after insulin during treatment with atropine. These data demonstrate that cholinergic mechanisms are involved in stimulatory and inhibitory pathways in the medication of the respective GH and PRL responses to insulin induced hypoglycaemia in man.