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PROLONGED FOLLICULAR PHASE AND DEPRESSED GONADOTROPHINS FOLLOWING HYSTERECTOMY AND CORPUS LUTE‐ECTOMY IN WOMEN WITH PREMENSTRUAL TENSION SYNDROME
Author(s) -
BÄCKSTRÖM T.,
SMITH S.,
LOTHIAN H.,
BAIRD D. T.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00162.x
Subject(s) - luteal phase , follicular phase , corpus luteum , ovulation , enucleation , endocrinology , medicine , menstrual cycle , hysterectomy , endocrine system , ovary , hormone , surgery
SUMMARY In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid‐luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterectomy for menstrual problems. In the luteal phase, before surgery, the concentration of progesterone and FSH was lower, while that of oestradiol was slightly higher, in women with PMS. Following enucleation of the corpus luteum, follicular development and ovulation recommenced more slowly in women with PMS compared to controls (time to ovulation: 21 (range 18–24, vs 19(14–20) d, P < 0.01). During the follicular phase there was no difference between the two groups in the concentration of oestradiol. The rise in concentration of FSH following enucleation was delayed in patients with PMS, and the serum FSH concentration was significantly lower during the late follicular phase of the cycle, but not during the mid follicular phase. The results suggest that these women with PMS have a more sensitive ‘feed‐back’ than the controls, resulting in a lower preovulatory FSH level even though the oestradiol levels were not different. The results also suggest that the abnormalities described during the preoperative luteal phase are associated with the delay in the initial FSH rise.