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ABNORMAL VITAMIN D METABOLISM IN PAGET'S DISEASE OF BONE
Author(s) -
GUILLARDCUMMING D. F.,
BEARD D. J.,
DOUGLAS D. L.,
JOHNSON S. K.,
LAWSONMATTHEW P. J.,
RUSSELL R. G. G.,
KANIS J. A.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00157.x
Subject(s) - medicine , hydroxyproline , paget's disease of bone , endocrinology , vitamin d and neurology , bone remodeling , alkaline phosphatase , bone disease , excretion , metabolism , calcifediol , disease , chemistry , enzyme , vitamin d deficiency , osteoporosis , biochemistry
SUMMARY We have studied several biochemical indices of bone turnover and vitamin D metabolism in 32 untreated patients with Paget's disease and in 32 age‐matched control subjects. Patients with Paget's disease, as expected, were characterized by high bone turnover, as judged by alkaline phosphatase and urinary excretion of hydroxyproline. Serum values of 24,25‐dihydroxyvitamin D 3 (24,25(OH) 2 D 3 ) and the ratio of 24,25(OH) 2 D 3 to 25‐OHD were significantly lower in patients than in control subjects. Serum concentrations of 1,25(OH) 2 D 3 were normal in Paget's disease. The distribution of values for 24,25(OH) 2 D 3 was log normal. On the basis of the normal range computed from control subjects, patients were divided into those with low or normal values for 24,25(OH) 2 D 3 . Disease activity, as judged by biochemical indices was significantly higher in the patients with the lower values of 24,25(OH) 2 D 3 . We conclude that Paget's disease is characterized by low circulating concentrations of 24,25(OH) 2 D 3 , particularly in patients with more extensive or severe disease.