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THE SCREENING OF PATIENTS WITH SUSPECTED THYROTOXICOSIS USING A SENSITIVE TSH RADIOIMMUNOASSAY
Author(s) -
EVANS MARGARET,
CROXSON M. S.,
WILSON T. M.,
IBBERTSON H. K.
Publication year - 1985
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1985.tb00143.x
Subject(s) - radioimmunoassay , medicine , endocrinology
SUMMARY A radioimmunoassay was optimized to measure serum TSH with maximum sensitivity (sTSH). With this assay sTSH was < 0·5 mIU/l in 100% of 64 patients with proven thyrotoxicosis and > $5 mIU/l in 92% of 76 normal subjects. sTSH correctly predicted the TSH response to TRH (Δ TSH) in 93% of 125 patients with suspected thyrotoxicosis. In this group thyrotoxicosis was excluded by an sTSH > $5 mIU/l in 52% of patients thus avoiding the need for further testing.