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BIOLOGICALLY ACTIVE PARATHYROID HORMONE IN FAMILIAL HYPOCALCIURIC HYPERCALCAEMIA
Author(s) -
ALLGROVE J.,
SANGAL A. K.,
LOW D. C.,
WELLER P. H.,
LOVERIDGE N.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb03472.x
Subject(s) - hypercalcaemia , parathyroid hormone , endocrinology , medicine , bioassay , biological activity , pseudohypoparathyroidism , chemistry , calcium , biology , in vitro , biochemistry , genetics
SUMMARY Biologically active PTH (bio‐PTH) has been assayed by the cytochemical bioassay in five members (three affected) of a family with typical features of familial hypocalciuric hypercalcaemia (FHH). Carboxy‐terminal immunoreactive PTH was undetectable and bio‐PTH was within the normal range in all the subjects regardless of whether or not they were hypercalcaemic. These results suggest that increased biological activity of circulating PTH cannot account for the hypercalcaemia of FHH.