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IODIDE ORGANIFICATION DEFECT IN A COLD THYROID NODULE: ABSENCE OF IODIDE EFFECT ON CYCLIC AMP ACCUMULATION
Author(s) -
DEMEESTERMIRKINE N.,
SANDE J. VAN,
DOR P.,
HEIMANN R.,
COCHAUX P.,
DUMONT J. E.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb03444.x
Subject(s) - organification , iodide , medicine , endocrinology , thyroid , chemistry , iodine , biology , inorganic chemistry , organic chemistry
SUMMARY A follicular adenoma of the thyroid was ‘hot’ one hour after 99m Tc pertechnetate administration, but ‘cold’24 h after 131 I iodide administration. Incubation of the tissue in vitro demonstrated a defect in iodide binding to proteins that was abolished by addition of an H2O2 generating system. In this tissue iodide failed to inhibit TSH‐induced cyclic AMP accumulation. The results show that iodide oxidation is required for its inhibitory action on cyclic AMP accumulation in human thyroid.