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MALIGNANT FOLLICLES OF A DIFFERENTIATED THYROID CARCINOMA RELEASING IODINATED THYROGLOBULIN INTO THE LYMPHATIC VESSELS
Author(s) -
And F. GEBEL,
STUDER H.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb03442.x
Subject(s) - thyroglobulin , thyroid carcinoma , thyroid , lymphatic system , endocrinology , medicine , staining , follicular carcinoma , pathology , carcinoma , follicular phase , lymph , chemistry , papillary carcinoma
SUMMARY Serial sections across a follicular thyroid carcinoma taken from a 71‐year‐old woman with hyperthyroidism and grossly elevated serum thyroglobulin were examined by PAS staining and autoradiographic techniques. PAS positive material, presumably thyroglobulin, was found in the interstitial network between follicles. Some of this material was autoradiographically positive for 125 I within 17 h after tracer application. Direct connections between the lumina of tumour follicles and the lymphatic vessels surrounding them were identified. These channels can explain the release of iodinated thyroglobulin by some differentiated carcinomas.