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RENAL 1,25‐DIHYDROXYVITAMIN D, PHOSPHATURIC, AND CYCLIC‐AMP RESPONSES TO INTRAVENOUS SYNTHETIC HUMAN PARATHYROID HORMONE‐(1‐34) ADMINISTRATION IN NORMAL SUBJECTS
Author(s) -
SLOVIK D. M.,
DALY MARGARET A.,
POTTS J. T.,
NEER R. M.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb03432.x
Subject(s) - medicine , endocrinology , parathyroid hormone , urinary system , hormone , excretion , chemistry , calcium
SUMMARY The exogenous administration of bovine parathyroid hormone or parathyroid extract has been used to differentiate states of parathyroid hormone resistance and parathyroid gland secretory failure, and in recent years to test renal 1,25‐dihydroxyvitamin D (1,25‐(OH) 2 ‐D) secretion. We evaluated the effect of synthetic human parathyroid hormone (hPTH‐(1–34)) administration on the renal 1,25‐(OH) 2 ‐D, phosphaturic and cyclic‐AMP responses in eleven normal young adults. The intravenous administration of 200 units of hPTH‐(1–34) over 10 min produced a 1.3‐5.4 fold increase ( P <0.01) in renal phosphate clearance and a 19–75 fold increase ( P < 0.0001) in urinary cyclic‐AMP excretion. Serum 1,25‐(OH) 2 ‐D levels showed a small and insignificant change at 2‐5 h and a significant ( P <0.05) but small (21 ± 24 pmol/1) increase at 7 h after the first injection. In eight subjects a second injection of hPTH‐(1–34) was given at 7 h. In these individuals serum 1,25‐(OH) 2 ‐D levels at 24 h were 40 ± 14 pmol/1 (44%) higher than baseline ( P <0.01), but were variable over the 24 h period. The present study shows that hPTH‐(1–34) produces renal phosphaturic and cyclic‐AMP responses in normals similar to those produced by bovine PTH preparations. However, the serum 1,25‐(OH) 2 ‐D response to one or two intravenous injections of hPTH‐(1–34) is small, variable, and inconsistent and, therefore, will not provide a consistent way of stimulating renal 1,25‐(OH) 2 ‐D secretion.