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TOTAL DEFICIENCY OF CORTICOSTEROID‐BINDING GLOBULIN
Author(s) -
ROITMAN A.,
BRUCHIS S.,
BAUMAN B.,
KAUFMAN H.,
LARON Z.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb01393.x
Subject(s) - endocrinology , transcortin , medicine , globulin , corticosteroid
SUMMARY An obese 15‐year‐old boy of Jewish Iranian origin who is the offspring of consanguineous parents was found to have very low levels of total cortisol in the plasma. Investigation of the family revealed a complete lack of cortisol‐binding‐globulin (CBG) in the proband and a sister, evidently the first cases of total CBG deficiency to be reported. The parents and a brother were found to have half the normal levels. This study indicates that CBG deficiency, a benign condition, is compatible with a codominant or recessive autosomal trait inheritance.