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THE EFFECT OF OESTROGEN (MESTRANOL) ON THE THYROTROPHIN RESPONSE TO THYROTROPHIN RELEASING HORMONE IN POSTMENOPAUSAL OOPHORECTOMISED WOMEN
Author(s) -
ABDALLA H. I.,
BEASTALL G. H.,
HART D. M.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00137.x
Subject(s) - medicine , endocrinology , mestranol , basal (medicine) , postmenopausal women , placebo , hormone , estrogen , population , research methodology , alternative medicine , environmental health , pathology , family planning , insulin
SUMMARY The thyrotrophin (TSH) responses to thyrotrophin releasing hormone (TRH) in 16 oophorectomised postmenopausal women on long term treatment with mestranol 24 μg daily were compared to those in 16 oophorectomised postmenopausal women on placebo treatment. No significant difference between the groups was found in either basal TSH levels or the TSH response to TRH. It is therefore unlikely that the difference in TSH response to TRH between men and women of reproductive age is due to a direct stimulatory effect of oestrogen in women.