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CORTICOTROPHIN RELEASING FACTOR: EFFECTS ON CIRCULATING GUT AND PANCREATIC PEPTIDES IN MAN
Author(s) -
LYTRAS N.,
GROSSMAN A.,
REES LESLEY H.,
SCHALLY A. V.,
BLOOM S. R.,
BESSER G. M.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00123.x
Subject(s) - motilin , medicine , endocrinology , pancreatic polypeptide , cholecystokinin , somatostatin , neurotensin , gastrin , gastric inhibitory polypeptide , gastrointestinal hormone , peptide hormone , peptide , vasoactive intestinal peptide , pancreatic function , neuropeptide , pancreas , secretion , glucagon , biology , hormone , receptor , biochemistry
SUMMARY As a CRF‐like peptide has been isolated from human gut, we investigated the effect of synthetic CRF‐41 100 μg on gut and pancreatic peptides in six normal subjects. There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen. In addition, there was no change in circulating met‐enkephalin. We conclude that the rise in pancreatic polypeptide seen after CRF administration may suggest a role for a CRF‐like peptide in the control of pancreatic function.