Premium
MATERNAL HYPERTHYROIDISM AND CONGENITAL MALFORMATION IN THE OFFSPRING
Author(s) -
MOMOTANI NAOKO,
ITO KUNIHIKO,
HAMADA NOBORU,
BAN YOSHIO,
NISHIKAWA YOSHIHIKO,
MIMURA TAKASHI
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00119.x
Subject(s) - medicine , euthyroid , offspring , incidence (geometry) , congenital hypothyroidism , gestation , endocrinology , pediatrics , pregnancy , thyroid , physiology , physics , biology , optics , genetics
SUMMARY Six hundred and forty‐three neonates from mothers with GRAVES' disease were examined for major malformations of external organs to compare the influence of maternal hyperthyroidism vs. ingestion of methimazole (MMI) during the first trimester on the incidence of congenital malformations. The subjects were divided into four groups according to maternal therapy and thyroid status during the first trimester as follows: (1) infants whose mothers did not receive MMI and were hyperthyroid (Group 1), (2) infants whose mothers did not receive MMI and were euthyroid (Group 2), (3) infants whose mothers received MMI and were hyperthyroid (Group 3) and (4) infants whose mothers received MMI and were euthyroid (Group 4). The prevalence of malformed infants in these four groups was 6·0% (three of 50), 0·3% (one of 350), 1·7% (two of 117) and 0·0% (none of 126), respectively. The incidence in Group 1 was significantly higher than that in Group 2 ( P < 0·01). There was no discernible dose dependency of MMI on the occurrence of malformations. These findings suggest that maternal uncontrolled hyperthyroidism may cause congenital malformations and that the beneficial role of MMI treatment outweighs its teratogenic effect, if any.