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THE INHIBITION BY ETOMIDATE OF THE 11β‐HYDROXYLATION OF CORTISOL
Author(s) -
FRY D. E.,
GRIFFITHS H.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00112.x
Subject(s) - etomidate , endocrinology , medicine , radioimmunoassay , hydrocortisone , chemistry , anesthesia , propofol
SUMMARY The effect of a sleep‐dose of etomidate on the plasma concentrations of cortisol, 11‐deoxycortisol and 17αOH‐progesterone was investigated in eight patients; two other patients received thiopentone. Blood samples were collected at 0, 15 and 30 min after etomidate or thiopentone when an injection of tetracosactrin was given and a final sample was collected at 60 min. The plasma cortisol response to tetracosactrin was depressed below normal in patients given etomidate, and the 11‐deoxycortisol response was very high, ranging from 36·4 to 184·7 nmol/1. The two patients that received thiopentone had a normal response to all steroids. The identity of the plasma 11‐deoxycortisol in two patients was confirmed by high‐performance liquid chromatographic separation and quantification by both spectrophotometric and radioimmunoassay measurements. These results suggest that a single dose of etomidate inhibits 11β‐hydroxy]ation of cortisol.