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FACTORS IN THE CONTROL OF PLASMA RENIN ACTIVITY AND CONCENTRATION IN TYPE 1 (INSULIN‐DEPENDENT) DIABETES
Author(s) -
DRURY P. L.,
BODANSKY H. J.,
ODDIE C. J.,
EDWARDS C. R. W.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00110.x
Subject(s) - supine position , medicine , endocrinology , plasma renin activity , diabetes mellitus , renin–angiotensin system , blood pressure , insulin
SUMMARY Possible factors involved in the control of plasma renin activity (PRA) and concentration (PRC) have been analysed in 49 patients with long‐standing Type 1 diabetes and in 40 healthy controls matched for age and sex. Eighteen of the diabetic subjects were clinically free of all microvascular and macrovascular complications of their disease (Group A); 31 had proliferative retinopathy (Group B). Both lying and standing PRA and PRC were similar in Group A and healthy controls. Mean PRA was 50–115% higher in Group B diabetics than in controls ( P <0·001 supine and erect) and 50–70% higher than in Group A diabetics ( P <0·05 supine and erect); PRC also was 60% higher in Group B than in Group A ( P <0·05 supine and erect). Control subjects showed significant falls in both PRA and PRC with increasing age, while Groups A and B showed significant falls in PRA or PRC with age. Group A showed a significant inverse correlation between systolic blood pressure and supine PRC ( r = ‐0·57), but this was not significant in the controls and was completely absent in Group B. With correction for the effect of age there were significant relationships of PRA and PRC with sodium excretion in the controls and in Group A, but not in Group B. PRA and PRC are thus normal in uncomplicated long‐standing Type 1 diabetes, but regulation of renin secretion appears to be impaired in patients with microvascular disease. Renin secretion inappropriate to their blood pressure and sodium status may contribute to maintenance of their relative hypertension.; Correspondence: Dr P. L. Drury, Department of Endocrinology, St Bartholomew's Hospital, London EC1A 7BE.