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VALUE OF THE 30 MIN ACTH‐TEST IN ASSESSING HYPOTHALAMIC‐PITUITARY‐ADRENOCORTICAL FUNCTION AFTER PITUITARY SURGERY IN CUSHING'S DISEASE
Author(s) -
KEHLET H.,
LINDHOLM J.,
BJERRE P.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00091.x
Subject(s) - medicine , cushing's disease , endocrinology , adrenal function , adrenocorticotropic hormone , adrenocortical insufficiency , pituitary disease , disease , adrenal insufficiency , hormone
Adrenocortical responses to a 30 min ACTH‐test were measured before pituitary surgery and 8‐12 d, 2‐3 months and 6 months after, in 13 patients with Cushing's disease. The decrease in adrenocortical response to the short ACTH‐test performed 8‐12 d postoperatively correlated with the outcome as assessed 6 months after surgery. Adrenocortical response to ACTH became subnormal or borderline 8‐12 d after surgery in patients demonstrating postoperative HPA insufficiency. These results add further support to the value of the short ACTH‐test in assessing integrated HPA function in various clinical situations.