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RELATIONS BETWEEN IMMUNOREACTIVE SOMATOMEDIN C, INSULIN AND T3 PATTERNS DURING FASTING IN OBESE SUBJECTS
Author(s) -
CAUFRIEZ A.,
GOLSTEIN J.,
LEBRUN P.,
HERCHUELZ A.,
FURLANETTO R.,
COPINSCHI G.
Publication year - 1984
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1984.tb00060.x
Subject(s) - medicine , endocrinology , somatomedin , insulin , concomitant , growth hormone , hormone
SUMMARY Plasma glucose, immunoreactive somatomedin‐C (Sm‐C), GH, insulin (IRI) and T3 were measured daily in 20 obese subjects before and during a 9‐day fast. Control levels of Sm‐C were normal and exhibited no significant correlation with any of the other parameters investigated. During fasting there were no consistent variations in GH, but significant decreases occurred in blood glucose, IRI, T3 and Sm‐C levels. While individual Sm‐C patterns varied widely, as a group the fasting Sm‐C values showed a positive correlation with the fasting IRI and T3 levels, and with control body weight. These findings suggest that the decrease in Sm‐C which occurs during caloric deprivation may be the result of concomitant decreases occurring in T3 and IRI levels.