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INCREASED SERUM CONCENTRATION OF T4‐BINDING GLOBULIN IN PATIENTS WITH HYPOGAMMAGLOBULINAEMIA
Author(s) -
LEVER A.,
BIRD DAPHNE,
BYFIELD P. G. H.,
LALLOZ M. R. A.,
WEBSTER A. D. B.,
HIMSWORTH R. L.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb03202.x
Subject(s) - medicine , endocrinology , globulin , gamma globulin , confusion , thyroxine binding globulin , thyroxine binding proteins , abnormality , thyroid function tests , thyroid , antibody , immunology , triiodothyronine , psychology , psychiatry , psychoanalysis
SUMMARY Patients with hypogammaglobulinaemia have been regularly found to have abnormal conventional thyroid function test results. The abnormality is due to an increased plasma concentration of T4‐binding globulin (TBG). As the prevalence of autoimmune thyroid disease is probably increased in hypogammaglobulinaemia this further abnormality in the plasma proteins may lead to diagnostic confusion. Administration of gammaglobulin by infusion causes a rapid but transient fall in plasma concentrations of TBG and T4 which is probably due to a temporary redistribution of the plasma proteins.