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A TEST OF 1,25‐DIHYDROXYVITAMIN D 3 SECRETORY CAPACITY IN NORMAL SUBJECTS FOR APPLICATION IN METABOLIC BONE DISEASES
Author(s) -
PRINCE R. L.,
WARK J. D.,
OMOND S.,
OPIE J. M.,
EISMAN J. A.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb03194.x
Subject(s) - endocrinology , medicine , basal (medicine) , homeostasis , pathological , circadian rhythm , metabolism , biology , insulin
SUMMARY The circulating concentration of 1,25‐dihydroxyvitamin D 3 [1,25‐(OH) 2 D 3 ] varies in man in response to a variety of physiological stimuli. In pathological states, random plasma 1,25‐(OH) 2 D 3 levels reflect the sum of the underlying pathological process and the homeostatic corrections to those perturbations. Hence random 1,25‐(OH) 2 D 3 levels do not allow differentiation as to whether changes in 1,25‐(OH) 2 D 3 production or metabolism are primary or secondary to other changes. Similarly random levels do not provide much insight into the reserve of 1,25‐(OH) 2 D 3 secretory capacity. We have developed a single infusion of parathyroid extract (PTE) as a test of 1,25‐(OH) 2 D 3 secretory capacity. Normal responses in twelve males and six females consisted of an increase in plasma 1,25‐(OH) 2 D 3 levels of 78% over basal in the male and 77% over basal in the female subjects. The peak response occurred 18–22 h after the PTE was administered. This test of 1,25‐(OH) 2 D 3 secretory capacity should prove useful in the evaluation of patients with metabolic bone disease. As part of this study, the diurnal plasma 1,25‐(OH) 2 D 3 level was examined in six males and seven females. There was no significant diurnal rhythm between 8.00 and 22.00 h.