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TRACKING OF INDIUM‐111‐OXINE LABELLED LYMPHOCYTES IN AUTOIMMUNE THYROID DISEASE
Author(s) -
POZZILLI P.,
POZZILLI C.,
PANTANO P.,
NEGRI M.,
ANDREANI D.,
CUDWORTH A. G.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00749.x
Subject(s) - thyroiditis , thyroid , medicine , autoimmune thyroiditis , graves' disease , autoimmune disease , pathogenesis , endocrinology , thyroid disease , immunology , pathology , disease
SUMMARY Peripheral lymphocytes (∼10 8 ) from 4 subjects affected by autoimmune thyroid disease (2 Hashimoto's thyroiditis, 1 primary myxoedema, 1 Graves' disease) and 4 normal subjects were labelled in vitro with 40 μCi of indium‐111‐oxine and, following autologous injection, the distribution of the cells in the body was investigated by gamma camera imaging. Lymphocytes in the thyroid were observed 24 h after injection in both patients with Hashimoto's thyroiditis and in the patient with primary myxoedema, but not in the patient with Graves' disease or in any of the controls. To our knowledge, this is the first report using this method to try and demonstrate lymphocytes in the thyroid gland, and supports the concept that cell‐mediated immunity may be playing an important role in the pathogenesis of Hashimoto's thyroiditis and primary myxoedema.