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INDIRECT EVIDENCE THAT THE ACTION OF CYPROTERONE ACETATE ON THE SKIN IS DUE TO A METABOLITE
Author(s) -
LYONS F.,
SHUSTER S.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00742.x
Subject(s) - cyproterone acetate , metabolite , endocrinology , medicine , cyproterone , action (physics) , chemistry , hormone , androgen , physics , quantum mechanics
SUMMARY Cyproterone acetate, applied as 1% solution in ethanol or isopropyl myristate, did not decrease the sebum excretion rate (SER) when applied to forehead skin of patients with acne, although SER is decreased when the drug is given systemically. The probable explanation is that cyproterone acetate owes its local action to a metabolite formed systemically. The present study shows this is unlikely to be the 17β‐hydroxy cyproterone acetate.