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HYPOGONADOTROPHIC HYPOGONADISM RESISTANT TO hCG AND RESPONSIVE TO LHRH: REPORT OF A CASE
Author(s) -
DONALD R. A.,
WHEELER M.,
SÖNKSEN P. H.,
LOWY C.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00583.x
Subject(s) - hypogonadotrophic hypogonadism , hypogonadotropic hypogonadism , endocrinology , medicine , testosterone (patch) , pulsatile flow , human chorionic gonadotropin , menotropins , gonadotropin , pregnancy , hormone , biology , ovulation induction , ovulation , genetics
SUMMARY The treatment of hypogonadotrophic hypogonadism with gonadotrophin releasing hormone (LHRH) has proved difficult in the past because of a progressive decline in the pituitary gonadotrophin response. These early studies generally used large relatively infrequent doses of natural LHRH (Davies et al. , 1977) or analogues with a prolonged action (Smith et al. , 1979). Recently, several reports have indicated that the lack of gonadotrophin response to LHRH can be overcome by frequent administration of low doses of natural LHRH in a pulsatile fashion (Belchetz et al. , 1978; Crowley et al. , 1980; Jacobson et al. , 1979; Schoemaker et al. , 1981; Valk et al. , 1980). However, it is not known whether those patients with hypogonadotrophic hypogonadism who fail to respond to human chorionic gonadotrophin (hCG) (Bardin et al. , 1969) are capable of responding to LHRH. In this case report of a patient with hypogonadotrophic hypogonadism who was resistant to prolonged hCG therapy, normal pituitary gonadotrophin and testosterone responses were obtained following pulsatile LHRH administration. The sperm count rose to 11 ± 10 6 /ml. His wife became pregnant and was delivered of a normal healthy female infant after an uneventful pregnancy.