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EVIDENCE FOR DOPAMINERGIC CONTROL OF ALDOSTERONE IN MAN
Author(s) -
FRISI.,
COSTA G.,
BUEMI M.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00052.x
Subject(s) - aldosterone , endocrinology , medicine , dopaminergic , dexamethasone , plasma renin activity , mineralocorticoid , renin–angiotensin system , chemistry , dopamine , blood pressure
SUMMARY The effect of L‐dopa (0·50 g, orally) on serum aldosterone, cortisol and potassium levels, plasma renin activity, and on urinary aldosterone excretion has been studied in normotensive subjects, before and after dexamethasone‐induced ACTH suppression. L‐dopa caused a further reduction in the levels of aldosterone but not cortisol, in the dexamethasone treated subjects. It is therefore suggested that the inhibitory action of L‐dopa on aldosterone secretion is mediated by the dopaminergic system.