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SUSTAINED GONADAL SUPPRESSION IN FERTILE WOMEN WITH THE LHRH AGONIST BUSERELIN
Author(s) -
HARDT W.,
SCHMIDTGOLLWITZER M.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00039.x
Subject(s) - buserelin , medicine , endocrinology , castration , luteinizing hormone , hormone , leuprorelin , endometriosis , agonist , endometrium , gonadotropin releasing hormone , receptor
SUMMARY Nine fertile women were treated with the luteinizing‐ hormone‐releasing hormone agonist buserelin (seven women received 800 ųg, two women 1200 ųg intranasally for up to 24 weeks). Both doses produced sustained suppression of ovarian function, accompanied by hot flushes. In five women chemical castration was established within 1 to 5 weeks, whereas in the other four volunteers transient peaks of serum oestradiol occurred between the 6th and 19th weeks. Thereafter low postmenopausal oestradiol levels persisted. Chemical castration was confirmed by hormonal parameters and endometrial biopsies (inactive endometrium). After cessation of treatment normal cyclical function occurred immediately. This reversible chemical castration may be useful for new therapeutical approaches in sexual hormone dependent diseases (endometriosis, precocious puberty, metastatic breast cancer).