Premium
SHOULD ONE MEASURE SERUM THYROGLOBULIN IN THE PRESENCE OF ANTI‐THYROGLOBULIN ANTIBODIES?
Author(s) -
BLACK E. G.,
HOFFENBERG R.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00036.x
Subject(s) - thyroglobulin , medicine , endocrinology , antibody , chemistry , radioimmunoassay , thyroid , immunology
SUMMARY Thyroglobulin auto‐antibodies (anti‐Tg) may affect measurement of serum thyroglobulin (Tg). We have assayed sera for Tg by RIA regardless of presence or absence of anti‐Tg, and this study was designed to assess the influence of anti‐Tg on the results. Binding of human anti‐Tg by the second antibody in our RIA (sheep anti‐rabbit immunoglobulin) is very low and sera containing anti‐Tg of varying titres do not systematically affect assay of Tg regardless of concentration. In our follow‐up study of patients with thyroid cancer, correlation between clinical state and Tg concentration is greater than 97% whether anti‐Tg is present or absent. These results indicate that in our assay anti‐Tg positive sera do not need to be excluded.