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CORRECTION BY BROMOCRIPTINE OF HYPOTHALAMIC DYSFUNCTION AND POST‐PRANDIAL HYPOGLYCAEMIC SYMPTOMS IN A 31‐YEAR‐OLD WOMAN
Author(s) -
CORCOS A. P.,
WEIDENFELD J.,
LEVY J.,
BARASH V.,
SIEGEL R. A.,
GUTMAN A.,
CHOWERS I.
Publication year - 1983
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1983.tb00022.x
Subject(s) - bromocriptine , medicine , endocrinology , metyrapone , glucagon , basal (medicine) , insulin , post prandial , hydrocortisone , hypoglycemia , insulin tolerance test , adrenocorticotropic hormone , prolactin , diabetes mellitus , insulin resistance , hormone , insulin sensitivity
SUMMARY A 31‐year old female presented with recurrent episodes of post‐prandial hypoglycaemic symptoms. Basal serum levels of ACTH, cortisol, GH, insulin and glucagon were normal. An adrenaline test demonstrated a normal peripheral response. An exercise test failed to produce ACTH, cortisol or FFA responses. Insulin (0·1 u/kg)‐induced‐hypoglycaemia failed to elevate serum ACTH, cortisol or GH. Metyrapone and ACTH tests were normal, demonstrating adequate hypophyseal and adrenal function. These findings suggested that the patient suffered from hypothalamic dysfunction. Brornocriptine (Parlodel, 7·5 mg/d for 5 weeks) resulted in an improved general condition, accompanied by a decrease in sugar consumption. Following treatment, FFA, ACTH and cortisol responses to exercise test were normal, as were ACTH, cortisol and GH responses to insulin‐induced hypoglycaemia. It is concluded that bromocriptine may be useful in the treatment of post‐prandial hypoglycaemic symptoms associated with hypothalamic dysfunction.