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MENSTRUAL FUNCTION AND SERUM PROLACTIN LEVELS AFTER LONG‐TERM BROMOCRIPTINE TREATMENT OF HYPERPROLACTINAEMIC AMENORRHOEA
Author(s) -
BERGH TORBJÖRN,
NILLIUS SVEN JOHAN,
WIDE LEIF
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb03175.x
Subject(s) - bromocriptine , prolactin , medicine , discontinuation , amenorrhea , endocrinology , menstruation , hyperprolactinaemia , chemotherapy , hormone , pregnancy , biology , genetics
SUMMARY Long‐term bromocriptine treatment was discontinued in thirty‐seven women with hyperprolactinaemic amenorrhoea. After cessation of therapy thirty of the thirty‐seven women became hyperprolactinaemic again with amenorrhoea or anovulatory bleeding. Seven of the women continued to have regular ovulatory menstruation but only three were normoprolactinaemic 3 months after stopping treatment. Two of the seven women had evidence of pituitary tumour regression. After the discontinuation they had nearly normal prolactin levels but during 2 years of follow up the serum prolactin levels slowly increased. In the twenty‐seven women with pre treatment prolactin levels below 100 μg/l there was no difference between the prolactin levels before starting and 1 month after stopping treatment, while the women with pretreatment prolactin levels above 100 μ/l had lower levels after therapy. Bromocriptine treatment seldom results in permanent cure of hyperprolactinaemic amenorrhoea.