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NOCTURNAL NATRIURESIS IN HYPERTHYROIDISM
Author(s) -
BELL G. M.,
SAWERS J. S. A.,
TOFT A. D.,
DOIG A.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb03162.x
Subject(s) - natriuresis , endocrinology , medicine , excretion , nocturnal , sodium , triiodothyronine , chemistry , urine , thyroid , organic chemistry
SUMMARY We measured urine flow and the renal excretion of total solute, sodium, potassium and calcium in eleven patients with hyperthyroidism before and after treatment. Mean nocturnal sodium excretion was significantly greater ( P < 0·05) during hyperthyroidism and was unaccompanied by any significant alterations in day time or 24‐h values. As a result of this nocturnal natriuresis in hyperthyroidism significant changes were noted in the ratios of day/night sodium excretion ( P < 0·005) and urinary flow ( P < 0·05). The change in ratio of day/night sodium excretion resulting from treatment of hyperthyroidism was shown to correlate significantly with the change in plasma total triiodothyronine (r=0·73, P < 0·01). Twenty‐four hour urinary calcium output was significantly greater ( P < 0·02) in hyperthyroidism but there was no significant alteration in the day/night pattern of excretion.