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IMMUNOLOGICAL DISTURBANCES IN TOXIC MULTINODULAR GOITRE AND ACTIVE GRAVES’DISEASE
Author(s) -
KIY Y.,
REZKALLAHIWASSO M. T.,
PERAÇOLI M. T. S.,
MOTA N. G. S.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb03142.x
Subject(s) - multinodular goitre , phytohaemagglutinin , medicine , antibody , graves' disease , thyroid , endocrinology , immunology , immunity , endemic goitre , peripheral blood , immune system , thyroidectomy
SUMMARY Cell‐mediated and humoral immunity were studied in seventeen patients with toxic multinodular goitre, ten with active Graves’disease and fourteen healthy controls. The study included determination of sheep erythrocyte and complement rosette‐forming cells in the peripheral blood, immunoglobulin levels, titres of microsomal antibodies and migration inhibition test using thyroid extract and phytohaemagglutinin. When compared with controls the patients showed a positive response to thyroid antigen in the leucocyte migration inhibition test. Microsomal antibodies were detected in seven out of ten active Graves’disease patients against two out of seventeen of those with toxic multinodular goitre. Significantly increased IgG and IgA and decreased IgM levels were found only in the toxic multinodular group. These data provide further evidence for immunological disturbances in toxic multinodular goitre.