Premium
SLEEP‐ASSOCIATED GONADOTROPHIN AND OESTRADIOL PATTERNS IN GIRLS WITH PRECOCIOUS SEXUAL DEVELOPMENT
Author(s) -
MATTHEWS M. J.,
PARKER D. C.,
REBAR R. W.,
JONES K. L.,
ROSSMAN L.,
CAREY D. E.,
YEN S. S. C.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb01633.x
Subject(s) - medicine , endocrinology , nocturnal , pulsatile flow , gonadotropin , luteinizing hormone , sleep (system call) , gonadotropin releasing hormone , follicle stimulating hormone , testosterone (patch) , hormone , biology , computer science , operating system
SUMMARY Circulating concentrations of gonadotrophins and oestradiol (E 2 ) during sleep were examined in six girls aged 5–10 years with precocious sexual development. All subjects exhibited nocturnal increments of LH and/or FSH. Gonadotrophin secretion appeared to vary from pulsatile release to random oscillations. Three subjects with LH pulses of greater than 5 miu/ml and a concomitant FSH rise had a temporal elevation of E 2 during sleep. The other three subjects with pulses of either LH or FSH of less than 5 miu/ml had no nocturnal rise in E 2 . These data suggest that the nocturnal elevation of E 2 results from pituitary release of both LH and FSH, leads to premature sexual development, and may be occasioned by inappropriate timing of hypothalamic gonadotrophin‐releasing hormone (LHRH) secretion.