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HYDROTESTOLACTONE LOWERS SERUM OESTRADIOL AND PRL LEVELS IN NORMAL MEN: EVIDENCE OF A ROLE OF OESTRADIOL IN PRL SECRETION *
Author(s) -
D'AGATA R.,
ALIFFI A.,
MAUGERI G.,
MONGIOI A.,
VICARI E.,
GULIZIA S.,
POLOSA P.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb01617.x
Subject(s) - endocrinology , medicine , basal (medicine) , prolactin , secretion , chemistry , hormone , insulin
SUMMARY The effect on serum PRL levels of lowering serum oestradiol (E 2 ) concentration by short‐term administration of an aromatase activity inhibitor, hydrotestolactone (HT), was studied in six healthy male subjects. After HT administration serum E 2 levels decreased from 68 ± 5±8 to 26 ± 2±5 pmol/1 (mean ± SE, P < 0±05). These E 2 changes were accompanied by a significant decrease in mean 2‐h PRL levels from 11±2 ± 2±1 to 6±5 ± 1±6 ng/ml mean ± SE, P < 0±05). The evaluation of individual percentage change from basal concentrations showed a varying decrease in all subjects. These findings suggest that under physiological conditions E 2 may be one of the factors which control blood PRL concentrations in men.