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OPIATES CONTROL ACTH THROUGH A NORADRENERGIC MECHANISM
Author(s) -
GROSSMAN A.,
BESSER G. M.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb01591.x
Subject(s) - medicine , endocrinology , opiate , (+) naloxone , antagonist , mechanism (biology) , receptor , physics , quantum mechanics
SUMMARY The administration of 16 mg of naloxone to six normal male subjects produced a significant rise in plasma cortisol. Pre‐treatment with the noradrenergic α 1 ‐antagonist, thymoxamine 0.2 mg/kg, blocked this rise. It is suggested that opiate inhibition of the pituitary—adrenal axis is mediated via a noradrenergic pathway.