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ABNORMAL PANCREATIC POLYPEPTIDE RESPONSE TO INTRAVENOUS GLUCOSE IN URAEMICS. A POSSIBLE MECHANISM BEHIND IMPAIRED GLUCOSE TOLERANCE IN URAEMIA
Author(s) -
HALLGREN R.,
FJELLSTROM K. E.,
LUNDQUIST G.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb01575.x
Subject(s) - medicine , endocrinology , insulin , basal (medicine) , insulin response , impaired glucose tolerance , insulin resistance , plasma glucose
SUMMARY Glucose handling and insulin secretion were studied in chronic haemodialysis patients and correlated with circulating levels of immunoreactive pancreatic polypeptide (PP). No correlation was found between the elevated basal levels of PP and the K‐rate or the maximum insulin response after a single intravenous injection of glucose. Fifty‐three per cent of the patients had a normal glucose tolerance defined as a K‐rate more than 1. This group of uraemics had a tendency to an exaggerated insulin response compared with the controls but no significant changes of serum‐PP levels after a glucose stimulus were observed. In contrast, uraemic patients with a K‐rate less than 1 and normal insulin response, showed significant increases of serum‐PP at 4 and 6 min after glucose administration. Among all uraemic patients we found a significant inverse correlation between the K‐rate and the early PP response (Pc0.05) and a significant positive correlation between the K‐rate and the early insulin response (P