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THE EFFECT OF PUBERTY AND SHORT‐TERM ORAL ADMINISTRATION OF TESTOSTERONE UNDECANOATE ON GH TESTS AND SEX‐STEROID RELATED PLASMA COMPOUNDS IN GH DEFICIENT PATIENTS
Author(s) -
DROP S. L. S.,
SABBECLAUS L.,
VISSER H. K. A.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00730.x
Subject(s) - medicine , endocrinology , testosterone (patch) , sex steroid , oxandrolone , short stature , steroid , steroid hormone , sexual maturity , androgen , growth hormone , hormone
SUMMARY In twelve boys and two girls, with idiopathic (partial) growth hormone deficiency diagnosed at prepubertal age, we studied the effect of spontaneous puberty (six patients) as well as the effect of sex‐steroid priming (eight patients). Six boys received testosterone undecanoate and two girls ethinyloestradiol for 5 days. Two pubertal patients showed a normal GH response, the patients primed with testosterone or oestrogen did not, despite a distinct effect on sex‐steroid related plasma compounds. Reevaluation of GH status appears to be worthwhile in GH deficient patients presenting with short stature, growth deceleration at an early pubertal age and delayed sexual maturation. Sex‐steroid priming is unlikely to alter the outcome of GH testing, whenever marked growth deceleration is evident at prepubertal age.