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BIOCHEMICAL AND CLINICAL EFFECTS OF FENCLOFENAC IN THYROTOXICOSIS
Author(s) -
PEARSON D. W. M,
RATCLIFFE WENDY A.,
THOMSON J. A.,
RATCLIFFE J. G.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00729.x
Subject(s) - medicine , endocrinology , triiodothyronine , hormone , thyroid , reverse triiodothyronine , reference range
SUMMARY Administration of the anti‐inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 ± 8·6 (SEM) nmol/l before therapy was normalized to 70 ± 6·4 nmol/l after administration of the drug for 7 days. Free T4 levels also decreased significantly but not to within the reference range in all subjects. Mean total triiodothyronine (T3) and reverse T3 levels declined from 6·2 ± 0·9 nmol/l and 0·63 ± 0·2 nmol/l respectively before therapy to 3·8 ± 0·5 nmol/l and 0·52 ± 0·1 nmol/l after 7 days' treatment but remained consistently elevated in all subjects. Clinical thyroid status remained unchanged despite these marked reductions in circulating thyroid hormone levels, suggesting that fenclofenac was of no therapeutic benefit.