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THE ROLE OF OPIATE PEPTIDES IN THE CONTROL OF PROLACTIN IN THE PUERPERIUM, AND TSH IN PRIMARY HYPOTHYROIDISM
Author(s) -
GROSSMAN A.,
WEST S.,
WILLIAMS J.,
EVANS J.,
REES L. H.,
BESSER G. M.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00722.x
Subject(s) - prolactin , endocrinology , medicine , hyperprolactinaemia , (+) naloxone , opiate , opioid peptide , endogeny , endogenous opioid , hormone , opioid , receptor
SUMMARY The role of endogenous opiate peptides in puerperal hyperpro‐lactinaemia, and in the control of TSH in hypothyroidism, has been investigated. Although exogenous opioids raise prolactin and TSH levels, 16 mg naloxone administered to women on days 2–4 of the puerperium produced no significant change in serum prolactin and the same dose of naloxone had no significant effect on serum TSH in six primary hypothyroid patients. There is little evidence that endogenous opioid peptides are major modulators of prolactin or TSH in man under these conditions.