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THE INFLUENCE OF EXOGENOUS OESTRADIOL BENZOATE ON THE PITUITARY RESPONSIVENESS TO LHRH DURING THE PUERPERIUM IN WOMEN
Author(s) -
VEMER H. M.,
ROLLAND R.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00714.x
Subject(s) - endocrinology , medicine , bromocriptine , hyperprolactinaemia , lactation , estradiol benzoate , gonadotropin , prolactin , estrogen , ovariectomized rat , hormone , pregnancy , biology , genetics
SUMMARY The FSH and LH response to 25 μg LHRH was measured in lactating women and the results compared to a similar group in whom lactation was suppressed by administration of bromocriptine shortly after delivery. The response was also measured in both groups after “challenge” with oestradiol benzoate. In lactating women the FSH response to LHRH was diminished following the oestradiol challenge, as compared with that in unchallenged women. At the same time the LH responses were low in both circumstances, indicating a negative feedback effect of oestradiol. However, the oestradiol challenge resulted in a significantly increased response of FSH and LH to LHRH in bromocriptine‐treated puerperal women, i.e. a positive feedback effect of oestradiol. We concluded that this and previous experiments favour the hypothesis that the lactational amenorrhoea during hyperprolactinaemia is caused by hypothalamic changes due to a predominance of the negative feedback system.