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PLASMA ANDROGENIC ACTIVITY IN WOMEN WITH ACNE VULGARIS AND IN HEALTHY GIRLS BEFORE, DURING AND AFTER PUBERTY
Author(s) -
ODLIND V.,
CARLSTRÖM K.,
MICHAËLSSON G.,
VAHLQVIST A.,
VICTOR A.,
MELLBIN T.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00713.x
Subject(s) - acne , medicine , endocrinology , biology , dermatology
SUMMARY The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increased during puberty, whereas SHBG decreased during the early stages before it increased and stabilized in late puberty. Healthy adult women and women with mild acne vulgaris had similar plasma concentrations of testosterone and SHBG. Women with severe acne vulgaris had testosterone levels in the same range but the SHBG levels were significantly lower than those of healthy women and women with mild acne. These results show a high androgenic activity in the intermediate stages of puberty, when acne vulgaris is a common complaint and an increased androgenic activity in adult women with severe acne vulgaris.