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THE ACUTE CHANGES IN THYROID STIMULATING IMMUNOGLOBULINS, THYROGLOBULIN AND THYROGLOBULIN ANTIBODIES FOLLOWING SUBTOTAL THYROIDECTOMY *
Author(s) -
BECH KARINE,
FELDTRASMUSSEN ULLA,
BLIDDAL H.,
DATE J.,
BLICHERTTOFT M.
Publication year - 1982
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1982.tb00712.x
Subject(s) - medicine , thyroglobulin , thyroidectomy , antibody , thyroid , endocrinology , gastroenterology , surgery , immunology
SUMMARY The acute changes in thyroid adenylate cyclase stimulating immunoglobulins (TACSI), TSH binding inhibiting immunoglobulins (TBII), thyroglobulin (Tg) and thyroglobulin antibodies (TgAb) in serum after subtotal thyroidectomy were studied in thirteen patients with Graves' disease (GD) and thirteen patients with non‐toxic goitre (NG). Prior to operation eight patients with GD were TACSI positive (mean ± SEM: 135·18%) and within 8 h following surgery TACSI increased and became positive in all thirteen patients (mean 172 ± 20%). There was a parallel increase in Tg and a decline in TgAb. A secondary rise in TACSI was observed 3–4 days after operation followed by a gradual fall which was associated with an increase in TgAb reaching a maximum 10 days after surgery. TACSI were still detectable 1 month postoperatively, but had disappeared by 3 months. In four of nine patients with GD TBII were present prior to operation. Immediately after surgery TBII decreased significantly ( P < 0·05) and two of the four patients who were TBII positive became permanently negative, while the other two patients remained positive. A transient increase of the mean TBII levels was observed 5 days after surgery. Two of thirteen patients with NG were TACSI positive before operation and no significant changes were observed after surgery. The mean levels were significantly lower than in GD. Tg was measurable in eleven patients and showed a lower increase than in GD following surgery. TgAb were present in two patients prior to operation but disappeared in one and in the other one the changes following surgery were similar to the changes in GD.