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ALTERED ENDOCRINE RESPONSE TO PARTIAL THYROIDECTOMY IN PROPRANOLOL‐PREPARED HYPERTHYROID PATIENTS
Author(s) -
FEELY J.,
CROOKS J.,
FORREST A. L.,
HAMILTON W. F. D.,
GUNN A.,
BROWNING MARGARET C. K.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb02970.x
Subject(s) - euthyroid , propranolol , endocrinology , medicine , endocrine system , thyroidectomy , prolactin , hormone , triiodothyronine , thyroid
SUMMARY The endocrine response to partial thyroidectomy in a group of twenty hyperthyroid patients prepared with propranolol alone was compared to that of a matched control group of ten euthyroid patients. In propranolol‐prepared patients the glucose response to surgery was reduced ( P < 0·05) for up to 4 h post‐operatively and biochemical hypoglycaemia was noted in one patient. Both thyroxine and triiodothyronine (T3) fell significantly, associated with a marked rise in reverse T3. Growth hormone levels were higher ( P <0·05) both pre‐and post‐operatively in propranolol‐prepared patients, whereas prolactin levels, although similar pre‐operatively, were lower ( P <0·05) in these patients post‐operatively. Cortisol and ACTH levels were lower ( P < 0·05) both before and following thyroidectomy in propranolol‐prepared patients. These results suggest that the endocrine response to surgical stress is markedly altered in propranolol‐prepared hyperthyroid patients.