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STUDIES ON THE RESPONSES OF PLASMA RENIN ACTIVITY AND ALDOSTERONE AND CORTISOL LEVELS TO DOPAMINERGIC AND OPIATE STIMULI IN MAN
Author(s) -
LIGHTMAN S. L.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb02746.x
Subject(s) - carbidopa , endocrinology , medicine , dopamine , aldosterone , dopaminergic , domperidone , plasma renin activity , (+) naloxone , renin–angiotensin system , mineralocorticoid , endorphins , chemistry , levodopa , opioid , receptor , blood pressure , disease , parkinson's disease
Evidence for a role of dopamine and endogenous opioids in the control of the secretion of renin and adrenal steroids was sought in man. The effects of l ‐dopa, l ‐dopa plus carbidopa, dopamine, domperidone and naloxone were studied on the renin and aldosterone responses to head‐up tilt. l ‐dopa diminished the rise in renin following tilt and this effect of l ‐dopa was abolished by carbidopa. Aldosterone was not significantly affected by any of the compounds. Cortisol secretion was stimulated by carbidopa plus l ‐dopa more than l ‐dopa alone, and was also increased by both dopamine and naloxone. The significance of these findings is discussed.