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PROLONGED GALACTORRHOEA IN A 6‐YEAR‐OLD GIRL WITH ISOSEXUAL PRECOCIOUS PUBERTY DUE TO A FEMINIZING ADRENAL TUMOUR
Author(s) -
DROP S. L. S.,
BRUINING G. J.,
VISSER H. K. A.,
SIPPELL W. G.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb02745.x
Subject(s) - medicine , bromocriptine , cyproterone acetate , endocrinology , precocious puberty , girl , prolactin , prepuberty , hormone , androgen , biology , genetics
A large cystic adrenal carcinoma was removed in toto from a 6½‐year‐old girl with isosexual precocious puberty treated with cyproterone‐acetate. Immediately following surgery, severe galactorrhoea developed, but was successfully treated with bromocriptine. The tumour fluid and pre‐operative plasma samples contained highly elevated levels of both oestrogens and androgens. In addition prolactin values were high. One year after adrenalectomy all plasma hormonal values were normal for age, but galactorrhoea could still be elicited. The prolonged galactorrhoea is most likely the result of excessive oestrogen‘priming’, whereas the hyperprolactinaemic effect of cyproterone acetate therapy remains uncertain.