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SOTALOL IN HYPERTHYROIDISM
Author(s) -
KAUR S.,
KRASSAS G.,
RAMSAY I.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00709.x
Subject(s) - sotalol , endocrinology , medicine , blood pressure , creatinine , heart rate , chemistry , atrial fibrillation
SUMMARY Ten hyperthyroid patients were studied before and after 2 weeks' β‐adrenoceptor blockade with sotalol. The following variables were measured: resting pulse rate, blood pressure, weight, thyroid hormone levels, plasma lipids, alkaline phosphatase, plasma glucose and insulin responses to oral glucose, bromsulph‐thalein retention and the 24‐h urinary excretion of calcium, hydroxyproline, creatine and creatinine. Sotalol produced a significant fall in pulse and blood pressure. Weight loss continued during treatment. No metabolic changes of any consequence were found. It is concluded that sotalol should not be used as the sole treatment of a patient with hyperthyroidism.