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THYROXINE AND TRIIODOTHYRONINE LEVELS IN THYROID VEIN BLOOD AND IN THYROID TISSUE OF PATIENTS WITH AUTONOMOUS ADENOMAS
Author(s) -
GHERI R. G.,
BORRELLI D.,
CICCHI P.,
LEGNAIOLI M.,
FABBRONI S.,
MODIGLIANI U.,
GHERI G.,
SERIO M.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00692.x
Subject(s) - thyroid , euthyroid , medicine , endocrinology , triiodothyronine , hormone , vein , thyroid nodules
SUMMARY Thyroxine (T4) and triiodothyronine (T3) concentrations were measured in peripheral and thyroid vein blood and in nodular and extranodular thyroid tissue from twenty‐four patients with autonomous thyroid nodules (AFTN); fifteen of these patients showed clinical signs of hyperthyroidism and nine were euthyroid. Thirteen patients with solitary non‐functioning thyroid adenomas who were clinically euthyroid, served as controls; samples of thyroid vein blood and normal thyroid tissue being obtained from the contralateral lobe. T4 (189·4 ± 27·2 nmol/l) and T3 (7·05 ± 2·03 nmol/l) concentrations were significantly higher in the thyroid vein blood of patients with AFTN compared with controls (T4 = 119 ± 9·1 nmol/l, P < 0·05; T3 = 2·3 ± 0·21 nmol/l, P < 0·01) whereas peripheral levels in the two groups were similar. The T3 concentrations (10·56 ± 4·12 nmol/g wet tissue) in autonomously‐functioning thyroid nodular tissue were significantly higher than those of extranodular (1·9 ± 0·62 nmol/g wet tissue, P < 0·01) and normal thyroid tissue (2·63 ± 0·43 nmol/g wet tissue, P < 0·05). The T4 levels were not different in the tissues examined. The concentrations of T4 and T3 in thyroid vein blood did not show any significant correlation with the hormone levels in thyroid tissue.