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BROMOCRIPTINE SUPPRESSES ACTH SECRETION FROM HUMAN PITUITARY TUMOUR CELLS IN CULTURE BY A DOPAMINERGIC MECHANISM
Author(s) -
ADAMS E. F.,
ASHBY M. J.,
BROWN SUSAN M.,
WHITE M. C.,
MASHITER K.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00691.x
Subject(s) - bromocriptine , endocrinology , medicine , dopaminergic , haloperidol , serotonergic , secretion , dopamine , serotonin , chemistry , prolactin , receptor , hormone
SUMMARY Bromocriptine (0·13–13 μM) significantly inhibited ACTH secretion in a dose‐dependent manner when added to cell cultures of a human corticotrophic adenoma for 24 h. Haloperidol (13 μM), but not serotonin (13 μM), blocked this inhibition but had no significant effect when added alone. In addition, dopamine (10 μM) reduced ACTH secretion during a 4‐h incubation, whereas serotonin (0·01–10 μM) was ineffective. An ectopic ACTH secreting lung carcinoid was non‐responsive to doses of bromocriptine up to 13 μM. These results demonstrate a direct suppressive action of bromocriptine on a human pituitary corticotrophic adenoma through dopaminergic rather than sero‐toninergic mechanisms.