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LACK OF SUPPRESSION OF INSULIN SECRETION BY EXERCISE IN PATIENTS WITH INSULINOMA
Author(s) -
JARHULT J.,
ERICSSON M.,
HOLST J.,
INGEMANSSON S.
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00679.x
Subject(s) - insulinoma , medicine , endocrinology , insulin , secretion , pancreatic hormone , insulin resistance
SUMMARY Serum glucose, insulin and glucagon concentrations were measured in three patients with insulin‐producing tumours of the pancreas while performing an exercise test. In contrast to the normal adrenergic inhibition of insulin release in response to exercise, plasma insulin concentration remained at a constant and high level during exercise in patients with insulinomas. Their plasma glucose concentrations fell during exercise and in the post‐exercise period. No significant changes occurred in plasma glucagon concentration. An exercise test may be a useful new diagnostic tool in organic hyperinsulinism.